Turning acne on/off via mTORC1
نویسنده
چکیده
Over the past 10 years, the increase in comprehension of the mechanisms behind acne has been truly exponential. Starting with the ethnological work of Cordain, accelerated by the epidemiological work of Adebamowo, supported by the clinical trials of Smith and Mann, Kwon, DiLandro and others, the interface of diet and acne is coming into focus. Melnik now presents an exceptional pair of papers that illustrate for dermatologists what translational research is all about. The Western diet, the role of dairy, FoxO1 and mTORC1, the interplay of agonists and antagonists, therapeutics present and future - the jigsaw puzzle is coming together.
منابع مشابه
mTORC1: Turning Off Is Just as Important as Turning On
mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.
متن کاملDietary intervention in acne
The purpose of this paper is to highlight the endocrine signaling of Western diet, a fundamental environmental factor involved in the pathogenesis of epidemic acne. Western nutrition is characterized by high calorie uptake, high glycemic load, high fat and meat intake, as well as increased consumption of insulin- and IGF-1-level elevating dairy proteins. Metabolic signals of Western diet are se...
متن کاملTHE RELATIONSHIP BETWEEN ACNE AND INCREASED BODy MASS INDEx
© 2013 The Authors. doi: 10.2340/00015555-1677 Journal Compilation © 2013 Acta Dermato-Venereologica. ISSN 0001-5555 Acne appears to represent a visible indicator disease of over-activated mammalian target of rapamycin complex 1 (mTORC1) signalling, an unfavour able metabolic deviation on the road to serious common Western diseases of civilisation associated with increased body mass index and i...
متن کاملAre therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1?
Acne pathogenesis has recently been linked to decreased nuclear FoxO1 levels and increased mTORC1 activity. This hypothesis postulates that antiacne agents either enhance nuclear FoxO activity or inhibit mTORC1. Benzoyl peroxide (BPO), by activation of oxidative stress-inducible kinases, increases nuclear FoxO levels promoting Sestrin3-mediated AMPK activation. Furthermore, BPO-derived ROS may ...
متن کاملPotential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne
Acne in adolescents of developed countries is an epidemic skin disease and has currently been linked to the Western diet (WD). It is the intention of this viewpoint to discuss the possible impact of WD-mediated nutrient signalling in the pathogenesis of acne. High glycaemic load and dairy protein consumption both increase insulin/insulin-like growth factor-1 (IGF-1) signalling (IIS) that is sup...
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عنوان ژورنال:
دوره 22 شماره
صفحات -
تاریخ انتشار 2013